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Production of canthin-6-one alkaloids by cell suspension cultures ofBrucea javanica(L.) Merr.

✍ Scribed by Karin C. -S. Liu; Shi-Lin Yang; Margaret F. Roberts; J. David Phillipson

Publisher: Springer
Year: 1990
Tongue: English
Weight: 291 KB
Volume: 9
Category: Article
ISSN: 0721-7714
DOI: 10.1007/bf00232297

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✦ Synopsis

Cell suspension cultures of Brucea javanica (L.) Merr. were used to determine culture growth characteristics and production of canthin-6-one alkaloids. The major alkaloids produced were canthin-6-one, 11-hydroxycanthin-6-one, 5-methoxycanthin-6-one and 11-methoxycanthin-6-one. Alkaloids were synthesised throughout the 36 day growth cycle of the cells with maximum amounts within the cells occurring between days 20 to 28; approximately 10% of the alkaloids were in the medium at day 24 rising to 45% at day 32.

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