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Production of a urokinase plasminogen activator-IgG fusion protein (uPA-IgG) in the baculovirus expression system

✍ Scribed by Thomas A. Kost; Diane M. Ignar; William C. Clay; John Andrews; Jeremy D. Leray; Laurie Overton; Christine R. Hoffman; Katherine E. Kilpatrick; Byron Ellis; David L. Emerson


Book ID
117522307
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
829 KB
Volume
190
Category
Article
ISSN
0378-1119

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Expression ofMet protein and urokinase-t
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Met protein encoded by MET oncogene is the high affinity receptor for hepatocyte growth factor (HGF)/scatter factor (SF). HGF/SF has to be cleaved in its heterodimeric form by the urokinase-type plasminogen activator (uPA) to become active as a ligand for Met receptor. The expression of Met protein