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Production of a novel tryptophan analog, β-1-indazole-L-alanine with tryptophan synthase of Escherichia coli

✍ Scribed by Hidehiko Tanaka; Katsuyuki Tanizawa; Takahiro Arai; Keiji Saito; Tsuyoshi Arai; Kenji Soda


Book ID
115917907
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
415 KB
Volume
196
Category
Article
ISSN
0014-5793

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Acetyl-beta-(1-azulenyl)-D,L-alanine has been synthesized in high overall yield by the malonic ester condensation procedure, and the racemate has been enzymatically resolved with acylase I from Aspergillus melleus. The enantiomerically pure L-amino acid is of interest as a blue-colored fluorescent t