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Production of a functional single chain antibody attached to the surface of a plant virus

✍ Scribed by Lisa Smolenska; Ian M Roberts; Deanne Learmonth; Andrew J Porter; William J Harris; T.Michael A Wilson; Simon Santa Cruz

Book ID
117110193
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
223 KB
Volume
441
Category
Article
ISSN
0014-5793

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Random mutagenesis of a template single-chain Fv (scFv) antibody generates a mutant library with members of varying ligand affinities; however, only a small population of these mutants exhibit strong (Kd approximately 1 nM) or improved affinities. We have therefore designed a chemiluminescent sandwi