PRODUCTION OF A BIOLOGICALLY ACTIVE HUMAN INTERLEUKIN 18 REQUIRES ITS PRIOR SYNTHESIS AS PRO-IL-18

Interleukin (IL)-18, a biomarker of huma

Interleukin (IL)-18, a biomarker of human ovarian carcinoma, is predominantly released as biologically inactive precursor

✍ Anna Maria Orengo; Marina Fabbi; Loredana Miglietta; Cristian Andreani; Milena B 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 801 KB

## Abstract Interleukin (IL)‐18 is a proinflammatory and immune‐enhancing cytokine, which exerts antitumor effects __in vivo__, mediated by the induction of interferon (IFN)γ. We previously reported that IL‐18 processing is defective in epithelial ovarian carcinoma (EOC) cells, which secrete an ina