Production of 6-aminopenicillanic acid by immobilized Pleurotus ostreatus

✍ Scribed by Michael Kluge; Joachim Klein; Fritz Wagner

• Publisher: Springer Netherlands
• Year: 1982
• Tongue: English
• Weight: 273 KB
• Volume: 4
• Category: Article
• ISSN: 0141-5492
• DOI: 10.1007/bf00132828

✦ Synopsis

6-Aminopenicillanic acid from penicillin V is produced by Pleurotus ostreatus immobilized by entrapment in a chitosan matrix. In these carriers the cell concentration increases after network formation by irreversible shrinking of the biocatalyst. Specific activity of the ciocatalyst for the hydrolysis reaction is 1,31 mol.min catalyst)-' . (g wet weight of corresponding to a relative activity of 38%. Catalytic half-life of immobilized Pl. ostreatus is 25 days compared to 2.5 days for free suspended cells.