Production, growth and handling of multicellular tumor spheroids
β Scribed by Peter W. Woodman; Michael D. Armour
- Book ID
- 105006232
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 288 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1573-0603
No coin nor oath required. For personal study only.
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## Abstract Mammalian multicellular tumor spheroids (MTS), grown in liquid culture medium, 0.23 to 0.32 mm in diameter and consisting of 4,500 to 12,100 cells, were exposed to three ultrasonic machines: a clinical diagnostic device with an emitted intensity of 13 mW/cm^2^, a therapeutic machine wit
h~ vivo volume growth of two murine tumor cell lines was compared by mathematical modeling to their volume growth as multicellular spheroids. Fourteen deterministic mathematical models were studied. For one cell line, spheroid growth could be described by a model simpler than needed for description