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Production and functional expression of an epitope-tagged human choline acetyltransferase

โœ Scribed by Isabelle Robert; Christiane Quirin-Stricker

Book ID
111639430
Publisher
Humana Press Inc
Year
1998
Tongue
English
Weight
83 KB
Volume
11
Category
Article
ISSN
0895-8696

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Choline acetyltransferase (ChAT; EC 2.3.1.6) catalyzes synthesis of acetylcholine from acetyl-CoA (AcCoA) and choline in cholinergic neurons. Mutations in CHAT cause potentially lethal congenital myasthenic syndromes associated with episodic apnea (ChAT-CMS). Here, we analyze the functional conseque