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Production and characterization of stable 177Lu–siRNA complex and kinetic studies in colon cancer cell lines

✍ Scribed by Mojtaba Fathi; Kamal Yavari; Mohammad Taghikhani; Mohammad Ghannadi Maragheh


Book ID
118430863
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
54 KB
Volume
44
Category
Article
ISSN
0009-9120

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CPT-11, a new semisynthetic derivative of camptothecin, is active in a number of tumor types in the clinic, including colon cancer. CPT-11 is a drug that is converted into the active metabolite SN-38 by a carboxylesterase. Experiments were performed to obtain more insight in the cellular characteris