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Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor

✍ Scribed by ALEXEI MIAGKOV; ADRIAN A. LOBITO; BINGZHI YANG; MARCELA F. LOPES; ROBERT N. ADAMS; GREGORY R. PALARDY; MICHELE M. JOHNSON; HUGH I. McFARLAND; MICHAEL J. LENARDO; DANIEL B. DRACHMAN


Book ID
111476806
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
685 KB
Volume
998
Category
Article
ISSN
0890-6564

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Myasthenia gravis (MG) is an autoimmune disease caused by T cell-dependent antibody-mediated reduction of acetylcholine receptors (AChR) at the neuromuscular junction. Immunization of animals with Torpedo californica AChR (TAChR) results in an experimental model of MG. We used the variable regions o