Carbon-11-labeled p a l m i t i c a c i d i s produced r o u t i n e l y a t Washington U n i v e r s i t y School of Medicine f o r s t u d i e s o f m y x a r d i a l netabolism. To accomodate t h e needs o f 8 -15 p r e p a r a t i o n s per week and t h e l a r g e amounts o f r a d i o a c t i
Production and Application of Synthetic Precursors Labeled with Carbon-11 and Fluorine-18
β Scribed by Richard A. Ferrieri
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 7 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
## Abstract The use of kinetic isotope effects (KIEs) for the shortβlived radionuclides ^11^C and ^18^F in the study of reaction mechanisms is described using some examples. Leaving group fluorine KIEs (__k__^18^/__k__^19^) have been utilized to determine the rateβlimiting step for nucleophilic aro
## Abstract The syntheses of isotopically labelled (β)β10β[^11^C/^13^C]βcolchicine and (β)β9β[^11^C/^13^C]β isocolchicine have been achieved from the reaction of (β)desmethylcolchicine with [^11^C/^13^C]βiodomethane. The radiolabelled compounds, (β)β10β[^11^C]βcolchicine (^11^Cβnβcolchicine) and (β