Prodrugs: Some thoughts and current issu
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Valentino J. Stella
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Article
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2010
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John Wiley and Sons
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English
⚖ 321 KB
The prodrug approach to resolving formulation, delivery, and toxicity limitations on problematic drugs has had its proponents and detractors. Over the last 10 years or so, about 20% of all new small molecule NCEs have been prodrugs-a number that will surprise some. As chemists begin to explore new c