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Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase

✍ Scribed by Lee, Melinda J. C.; Nagasawa, Herbert T.; Elberling, James A.; DeMaster, Eugene G.

Book ID
115467792
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
529 KB
Volume
35
Category
Article
ISSN
0022-2623

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Nitroxyl (HNO) is the aldehyde dehydrogenase (AlDH) inhibitor produced by catalase action on cyanamide. Incubation of N-acetyl-L-cysteine (NAC), a reagent with a free sulfhydryl group, with Piloty's acid (a nitroxyl generator) suggested that NAC was acting as a competitive "trap" for nitroxyl. Eluci