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Prodrugs of 6-thiopurines: Enhanced delivery through the skin

✍ Scribed by K. B. Sloan; M. Hashida; J. Alexander; N. Bodor; T. Higuchi


Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
918 KB
Volume
72
Category
Article
ISSN
0022-3549

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In the present work, we report the possibility of modifying the electrostatic properties of the skin by treating human epidermis with compounds whose structures possess a large molecular dipole moment. Data are presented showing that such a modification can be used to enhance dermal drug delivery. I