Prodromal myeloproliferative neoplasms: The 2008 WHO classification

✍ Scribed by Hans Michael Kvasnicka; Juergen Thiele

• Book ID: 101438492
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 329 KB
• Volume: 85
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.21543

✦ Synopsis

Abstract

The concept of prodromal chronic myeloproliferative neoplasms has been endorsed by the WHO classification implicating a stepwise evolution of disease. Histology of the bone marrow (BM) and borderline to mildly expressed clinical features play a pivotal role for diagnosing prefibrotic‐early primary myelofibrosis. By lowering the platelet count for essential thrombocythemia and regarding BM morphology, early manifestations are tackled. Pre‐polycythemic stages of polycythemia vera with a low hemoglobin level at onset are diagnosed by positive JAK2V617F mutation status, a low erythropoietin value, and characteristic BM features. The revised WHO classification incorporates hematological, morphological, and moleculargenetic parameters to generate a consensus‐based working diagnosis. Am. J. Hematol., 2010. © 2009 Wiley‐Liss, Inc.