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Processing of the β-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutation

✍ Scribed by Felsenstein, Kevin M.; Lewis-Higgins, Lore


Book ID
123529024
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
469 KB
Volume
152
Category
Article
ISSN
0304-3940

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas