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Processing of Alzheimer's Amyloid Precursor Protein during H2O2-Induced Apoptosis in Human Neuronal Cells

โœ Scribed by Liang Zhang; Boyu Zhao; David T. Yew; John W. Kusiak; George S. Roth


Book ID
115580314
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
257 KB
Volume
235
Category
Article
ISSN
0006-291X

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Altered proteolysis of the amyloid precursor protein (APP) may play an important role in Alzheimer disease (AD). To better understand the role of mutant APP in the pathogenesis of the disease, we stably overexpressed the mutant APP717F approximately twofold vs. the endogenous wild-type gene in sever