International Symposium on Engineering under Uncertainty: Safety Assessment and Management (ISEUSAM - 2012) is organized by Bengal Engineering and Science University, India during the first week of January 2012 at Kolkata. The primary aim of ISEUSAM 2012 is to provide a platform to facilitate the discussion for a better understanding and management of uncertainty and risk, encompassing various aspects of safety and reliability of engineering systems. The conference received an overwhelming response from national as well as international scholars, experts and delegates from different parts of the world. Papers received from authors of several countries including Australia, Canada, China, Germany, Italy, UAE, UK and USA, besides India. More than two hundred authors have shown their interest in the symposium. The Proceedings presents ninety two high quality papers which address issues of uncertainty encompassing various fields of engineering, i.e. uncertainty analysis and modelling, structural reliability, geotechnical engineering, vibration control, earthquake engineering, environmental engineering, stochastic dynamics, transportation system, system identification and damage assessment, and infrastructure engineering.