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ProbSeq—a fragmentation model for interpretation of electrospray tandem mass spectrometry data

✍ Scribed by John Skilling; Richard Denny; Keith Richardson; Phillip Young; Thérèse McKenna; Iain Campuzano; Mark Ritchie

Publisher
Hindawi Publishing Corporation
Year
2004
Tongue
English
Weight
108 KB
Volume
5
Category
Article
ISSN
1531-6912

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✦ Synopsis

We describe a probabilistic peptide fragmentation model for use in protein databank searching and de novo sequencing of electrospray tandem mass spectrometry data. A probabilistic framework for tuning of the model using a range of well-characterized samples are introduced. We present preliminary results of our tuning efforts.

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