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Problems in estimating hemodynamic response parameters from fMRI data

✍ Scribed by James A. Sorenson; Xiaoming Wang

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 603 KB
Volume: 4
Category: Article
ISSN: 1065-9471
DOI: 10.1002/(sici)1097-0193(1996)4:4<265::aid-hbm4>3.0.co;2-1

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✦ Synopsis

The temporal (time-analysis) component of the statistical parametric mapping of the method of Friston et al. ([1994]: Human Brain Mapping 1:153-171) is evaluated using simulated time-course data sets and images acquired during a motor-task activation study. The results indicate that their method for estimating hemodynamic delay parameters is unreliable when the hemodynamic delay time is greater than 1-2 image frames. Problems also arise when system noise is present in addition to physiologic noise. These conditions apply for most task-activation studies with image acquisition rates (TRs) shorter than about 3 sec, and for images acquired at field strengths below 3 3 tesla. Modifications are suggested that inay make their method usable under these conditions. r: 1997 Wile?-Liss. Inc.

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