Problems associated with use of the Nin-cyclohexyloxycarbonyl (Hoc) group for tryptophans

✍ Scribed by Hideki Nishio; Yuji Nishiuchi; Tatsuya Inui; Kumiko Yoshizawa-Kumagaye; Terutoshi Kimura

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 134 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01156-4

✦ Synopsis

During HF reaction in the presence of anisole or p-cresol, a side reaction was observed associated with use of the N in -cyclohexyloxycarbonyl (Hoc) group for tryptophan (Trp). The structure of the modi®ed Trp and the HF conditions for suppressing this side reaction are described.