✦ LIBER ✦

Problems and paradigms: A mammalian molecular clock?

✍ Scribed by Simon Easteal

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 641 KB
Volume: 14
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950140613

No coin nor oath required. For personal study only.

✦ Synopsis

The molecular clock hypothesis remains controversial more than a quarter of a century after it was first proposed. A variety of approaches have been applied to testing the molecular clock in mammals. In many of these studies apparent refutation of the molecular clock has been based on false assumptions about the pattern of mammalian evolution. With a few exceptions there now appears to be little evidence for variation in the rate of molecular evolution among mammalian lineages, although comparison of more genes and proteins among a greater variety of mammalian orders is needed before a definitive conclusion can he reached on the issue.

📜 SIMILAR VOLUMES

Problems and paradigms: Molecular proble

Problems and paradigms: Molecular problems of positional information

✍ Lewis Wolpert 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB 👁 1 views

## Problems and Paradigms will feature discussions of fundamental unsolvedprob-Iems in basic biology and ideas for investigating them. In this article, Lewis Wolpert discusses the nature of pattern formationand the possibilities for applying molecular approaches to its analysis.

Problems and paradigms: Is segmentation

Problems and paradigms: Is segmentation generic?

✍ Stuart A. Newman 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 896 KB

When two populations of cells within a tissue mass differ from one another in magnitude or type of intercellular adhesions, a boundary can form within the tissue, across which cells will fail to mix. This phenomenon may occur regardless of the identity of the molecules that mediate cell adhesion. If

Problems and paradigms: Homoeotic select

Problems and paradigms: Homoeotic selector genes – a working definition

✍ Peter A. Lawrence 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB 👁 1 views

Preferential expression of the maternally derived X chromosome in the mouse yolk sac. Cell 12, 18 TAKAGI, N. & SASAKI, M. (1975). Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature 256,640-641. 19 HARPER, M. I., FOSTEN, M. & MONK, M.

Problems and paradigms: Paramutation – a

Problems and paradigms: Paramutation – a puzzle ripe for solution?

✍ J. R. S. Fincham 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB 👁 1 views

Toward construction of a self-sustained

Toward construction of a self-sustained clock-like expression system based on the mammalian circadian clock

✍ Dmitri Chilov; Martin Fussenegger 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB 👁 2 views

Problems and paradigms: Dystrophin as a

Problems and paradigms: Dystrophin as a mechanochemical transducer in skeletal muscle

✍ Susan C. Brown; Jack A. Lucy 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 923 KB

## Abstract This review is primarily concerned with two key issues in research on dystrophin: (1) how the protein interacts with the plasma membrane of skeletal muscle fibres and (2) how an absence of dystrophin gives rise to Duchenne muscular dystrophy. In relation to the first point, we suggest t