Problem of using cases with genetic anomalies as a reference group in case-control studies on drug use and birth defects

Selection of controls in case-control st

Selection of controls in case-control studies on maternal medication use and risk of birth defects

✍ Marian K. Bakker; Hermien E.K. de Walle; Aileen Dequito; Paul B. van den Berg; L 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

## Abstract ## BACKGROUND: In case‐control studies on teratogenic risks of maternal drug use during pregnancy, the use of normal or malformed controls may lead to recall‐bias or selection bias. This can be avoided by using controls with a genetic disorder. However, researchers are hesitant to use