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Probing the Pro- and Anti-Coagulant Interactions of Thrombin

✍ Scribed by Treuheit, Nicholas A.; Komives, Elizabeth A.


Book ID
119209562
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
39 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract The ASPP proteins are apoptosis regulators: ASPP1 and ASPP2 promote, while iASPP inhibits, apoptosis. The mechanism by which these different outcomes are achieved is still unknown. The C‐terminal ankyrin repeats and SH3 domain (ANK‐SH3) mediate the interactions of the ASPP proteins with