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Probing the Mode of Asymmetric Induction of Biginelli Reaction Using Proline Ester Salts

✍ Scribed by Jeong-Hun Sohn; Hyun-Moo Choi; Sunjung Lee; Seewon Joung; Hee-Yoon Lee


Book ID
102172308
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
135 KB
Volume
2009
Category
Article
ISSN
1434-193X

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The present study demonstrates the first enantioselective version of the Petasis reaction (boronic Mannich reaction), using glyoxylic acid, morpholine and a homochiral boronic ester as the chiral auxiliary. Chiral boronic esters are readily prepared by condensation of vinylboronic acids and chiral 1