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Probing the effect of Heat Shock Protein 70 on the aggregation of α-Synuclein

✍ Scribed by Spiegel, Evan T.; Jones, Phill; McLean, Pamela; Hyman, Brad; Zipfel, Warren R.


Book ID
119204919
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
38 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract The fibrillization of α‐synuclein (α‐syn) is a key event in the pathogenesis of α‐synucleinopathies. Mutant α‐syn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides α‐syn, Lewy