Probing Phosphane-Mediated [2+1] Annulation Reactions

✍ Scribed by Xu-Guang Liu; Yin Wei; Min Shi

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 506 KB
• Volume: 2010
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200901235

✦ Synopsis

Abstract

Phosphane‐mediated cyclizations between α‐keto nitriles and methylidenemalononitriles, producing highly functionalized cyclopropanes in good to excellent yields, are reported. The presence of strongly electron‐withdrawing cyano groups directly bound to the ketone carbonyl groups is believed to play a critical role in these transformations.