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Probing of contacts betweenEcoRII DNA methyltransferase and DNA with the use of substrate analogs and molecular modeling

โœ Scribed by E. V. Koudan; M. G. Brevnov; O. M. Subach; O. A. Rechkoblit; J. M. Bujnicki; E. S. Gromova


Book ID
110174498
Publisher
SP MAIK Nauka/Interperiodica
Year
2007
Tongue
English
Weight
516 KB
Volume
41
Category
Article
ISSN
0026-8933

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Molecular Modeling and Molecular Dynamic
โœ Narender Singh; Alfonso Dueรฑas-Gonzรกlez; Frank Lyko; Joseโ€…L. Medina-Franco ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 660 KB

## Abstract **A series of DNA** methyltransferaseโ€…1 (DNMT1) inhibitors were modeled by docking and molecular dynamics studies to rationalize their activity. Our findings will be valuable in guiding research efforts toward the rational design and virtual screening of novel DNMT inhibitors.magnified