Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

Enhanced cell culture performance using

Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

✍ Bruno Figueroa Jr.; Eric Ailor; Douglas Osborne; J. Marie Hardwick; Mitchell Ref 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 495 KB 👁 3 views

## Abstract Mammalian cells are used for the production of numerous biologics including monoclonal antibodies. Unfortunately, mammalian cells can lose viability at later stages in the cell culture process. In this study, the effects of expressing the anti‐apoptosis genes, __E1B‐19K__ and __Aven__,