𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Probing Molecular Cavities in α-Cyclodextrin Solutions by Xenon NMR

✍ Scribed by Kristin Bartik; Michel Luhmer; Stephen J. Heyes; Robert Ottinger; Jacques Reisse

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
94 KB
Volume
109
Category
Article
ISSN
1064-1866

No coin nor oath required. For personal study only.

✦ Synopsis

Xe NMR has been used to investigate intermolecular interacare used for the solubilization and encapsulation of drugs, tions between xenon and a-cyclodextrin in H 2 O and in DMSO. perfumes, and flavorings (19, 20). A most interesting appli-Nuclear Overhauser enhancement effects confirmed the formation cation has been their use as models of the active sites of of a xenon-cyclodextrin complex. Chemical shifts were measured hydrolytic enzymes (21, 22). Cyclodextrins (CD) are in solutions containing different concentrations of a-cyclodextrin known to complex rare gases ( 23). An X-ray structure has and in solutions containing linear oligosaccharides. The experibeen determined for the a-CD-krypton complex (24) and mental data are interpreted on the basis of a three-site model solid-state xenon NMR data have been reported for the afor xenon. The binding characteristics of the xenon-cyclodextrin . To our knowledge, no solution system, including the 129 Xe NMR chemical shift in the cavity and studies have been undertaken on a-CD-noble gas comthe equilibrium constants, were determined and are discussed.

plexes. Exploring further the possibilities of using the xenon

📜 SIMILAR VOLUMES

Inclusion complex formation of captopril
Inclusion complex formation of captopril with α- and β-cyclodextrins in aqueous solution: NMR spectroscopic and molecular dynamic studies
✍ Yoichi Ikeda; Sohko Motoune; Toshikazu Matsuoka; Hidetoshi Arima; Fumitoshi Hira 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

The inclusion complex formation of alpha-cyclodextrin (alpha-CyD), beta-cyclodextrin (beta-CyD), and 2-hydroxylpropyl-beta-cyclodextrin (HP-beta-CyD) with an angiotensin converting enzyme inhibitor, captopril, in aqueous solution was studied by (1)H- and (13)C-nuclear magnetic resonance spectroscopi

Comparison of the complexation between m
Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies
✍ Thao Do Thi; Koen Nauwelaerts; Matheus Froeyen; Luc Baudemprez; Michiel Van Spey 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 400 KB

Complexation in solution between methylprednisolone and three different cyclodextrins [2-hydroxypropyl-b-cyclodextrin (HP-b-CD), g-cyclodextrin (g-CD), and 2-hydroxypropyl-g-cyclodextrin (HP-g-CD)] was studied using phase solubility analysis, one and twodimensional 1 H-NMR and molecular modeling. Es

Molecular complexes of explosives with c
Molecular complexes of explosives with cyclodextrins I. Characterization of complexes with the nitramines RDX, HMX and TNAZ in solution by 1H NMR spin-lattice relaxation time measurements
✍ S. Cahill; S. Bulusu 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 442 KB

## Abstract Inclusion complex formation between the explosive molecules of the nitramine type, RDX, HMX and TNAZ, and cyclodextrins (α, β and γ) was studied in aqueous solution by means of ^1^H spin–lattice relaxation time (__T__~1~) measurements. The results show that nitramines bind to cyclodextr