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Probabilistic diagnosis in linkage analysis of bipolar disorder: Putting weights on the fringe

✍ Scribed by Paul Van Eerdewegh; Susan L. Santangelo; Hang Lee; Nan M. Laird; Deborah Blacker

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 107 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<693::aid-gepi24>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

We explored the utility of probabilistic weighting of fringe phenotypes in linkage analysis of bipolar disorder for the GAW10 chromosome 18 data. Four liability classes were assigned probabilistic weights based on the estimated probability that the case was a true bipolar. The weights were incorporated in parametric and nonparametric, single and multipoint analyses.

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