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Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

✍ Scribed by Alessandra Ianari; Tiziana Natale; Eliezer Calo; Elisabetta Ferretti; Edoardo Alesse; Isabella Screpanti; Kevin Haigis; Alberto Gulino; Jacqueline A. Lees

Book ID
113523862
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
1010 KB
Volume
15
Category
Article
ISSN
1535-6108

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## Abstract The retinoblastoma protein (pRb105) is a true tumor suppressor as deregulation of the Rb pathway by either mutation of pRb105 itself or other proteins in the pathway, such as p16INK4a, occur in most cancers. This prototypical family member, along with the related p107 and p130, are invo