Proapoptotic function of FHIT gene
β Scribed by Zhe-fu Qiu; De-min Han; Luo Zhang; Wei Zhang
- Book ID
- 107466816
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2006
- Tongue
- English
- Weight
- 422 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1000-9604
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π SIMILAR VOLUMES
The 3p14.2 chromosome region, which contains the FHIT gene and the FRA3B fragile site, is frequently altered in carcinomas. We analyzed the expression of the FHIT gene in 21 Burkitt's lymphoma cell lines and normal lymphoid populations. Seventeen (80%) of these cell lines had a common aberrant FHIT
Chromosomal aberrations and inactivation of tumour suppressor genes are frequent in acute leukaemia. To determine whether the FHIT gene is involved in the development of leukaemia, we examined the FHIT transcript in 65 leukaemia cell lines, 5 fresh acute leukaemia patients at diagnosis and in comple