Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1

The Human IGF1R IRES likely operates thr

The Human IGF1R IRES likely operates through a Shine–Dalgarno-like interaction with the G961 loop (E-site) of the 18S rRNA and is kinetically modulated by a naturally polymorphic polyU loop

✍ Zheng Meng; Nateka L. Jackson; Oleg D. Shcherbakov; Hyoungsoo Choi; Scott W. Blu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 433 KB

## Abstract __IGF1R__ is a proto‐oncogene with potent mitogenic and antiapoptotic activities, and its expression must be tightly regulated to maintain normal cellular and tissue homeostasis. We previously demonstrated that translation of the human __IGF1R__ mRNA is controlled by an internal ribosom