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Pro-inflammatory cytokines downregulate platelet derived growth factor-α receptor gene expression in human osteoblastic cells

✍ Scribed by Kemal N. Kose; Jing-Feng Xie; David L. Carnes; Dana T. Graves

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 1007 KB
Volume: 166
Category: Article
ISSN: 0021-9541
DOI: 10.1002/(sici)1097-4652(199601)166:1<188::aid-jcp20>3.0.co;2-a

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✦ Synopsis

1988). PDGF is the prototypical wound healing hormone. There are two different PDGF polypeptides that are 56% homologous and encoded by different genes. The PDGF-A and PDGF-B genes are independently regulated. PDGF exists as three different dimers of these gene products; PDGF-AA, PDGF-BB, and PDGF-AB. There are also two different PDGF receptors: the PDGF alpha receptor (binds PDGF-AA, PDGF-BB and PDGF-AB) and the PDGF-beta receptor (binds PDGF-BB and PDGF-AB) (Seifert et al., 1989; Matsui et al., 1989). The capacity of a cell to respond to PDGF-AA will depend specifically upon the number of PDGF alpha receptors, while the capacity to respond to PDGF-BB is dependent upon the number of either alpha or beta receptors .

Support for the importance for PDGF in osseous metabolism comes from our studies and studies by others indicating that: (1) PDGF stimulates mitogenesis and migration in osteoblastic cells

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