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PRO-APOPTOTIC EFFECT OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE INHIBITORS ON HUMAN MUSCLE CELLS IN VITRO

✍ Scribed by Svitlana V Demyanets; Christoph Kaun; J Pammer; Stefan Pfaffenberger; Tomas W Weiss; Gerald Maurer; Richard Pacher; Kurt Huber; Johann Wojta


Book ID
116342312
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
56 KB
Volume
13
Category
Article
ISSN
1054-8807

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✍ Ariane Mallat; Anne-Marie Preaux; Sylvie Blazejewski; Daniel Dhumeaux; Jean Rose πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 685 KB

During hepatic fibrogenesis, Ito cells proliferate, acquire a myofibroblastlike phenotype and synthesize increased amounts of extracellular matrix components. In this study, we have assessed the effects of simvastatin, an inhibitor of hydroxy-methylglutaryl-coenzyme A reductase, on the growth of hum