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PRNP polymorphisms in Chinese ovine, caprine and bovine breeds

✍ Scribed by L. Zhang; N. Li; B. Fan; M. Fang; W. Xu

Book ID
108633104
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
108 KB
Volume
35
Category
Article
ISSN
0268-9146

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## Summary A resequencing approach was adopted to identify sequence variants in the __PRNP__ gene that may affect susceptibility or resistance to bovine spongiform encephalopathy. The entire __PRNP__ gene (>21 kb) was sequenced from 26 chromosomes from a group of Holstein‐Friesian cows, as well as

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## Summary Twenty‐four microsatellite sites with at least three repeats were found in the bovine prion protein gene (__PRNP__) and 23 in the ovine __PRNP__ gene. Eight microsatellite sites were polymorphic in cattle and six in sheep with up to 10 alleles per site. In many cases allelic DNA fragment