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PRKAR1A gene analysis and protein kinase A activity in endometrial tumors

✍ Scribed by Tsigginou, A.; Bimpaki, E.; Nesterova, M.; Horvath, A.; Boikos, S.; Lyssikatos, C.; Papageorgiou, C.; Dimitrakakis, C.; Rodolakis, A.; Stratakis, C. A.; Antsaklis, A.


Book ID
118744115
Publisher
Bioscientifica
Year
2012
Tongue
English
Weight
287 KB
Volume
19
Category
Article
ISSN
1351-0088

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PRKAR1A encodes the regulatory subunit type 1-alpha (RIalpha) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA). Inactivating PRKAR1A mutations are known to be responsible for the multiple neoplasia and lentiginosis syndrome Carney complex (CNC). To date, at least 117 patho