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Prion Strain Mutation and Selection

✍ Scribed by Collinge, J.


Book ID
126881366
Publisher
American Association for the Advancement of Science
Year
2010
Tongue
English
Weight
393 KB
Volume
328
Category
Article
ISSN
0036-8075

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## Abstract ## Objective: Transgenic (Tg) mice expressing chimeras of mouse and human prion proteins (PrPs) have shorter incubation periods for Creutzfeldt‐Jakob disease (CJD) prions than mice expressing full‐length human PrP. Increasing the sequence similarity of the chimeric PrP to mouse PrP, by

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