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Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene

✍ Scribed by S. Krasemann; I. Zerr; T. Weber; S. Poser; H. Kretzschmar; G. Hunsmann; W. Bodemer


Book ID
116109969
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
287 KB
Volume
34
Category
Article
ISSN
0169-328X

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Inherited prion diseases are characterized by mutations in the PRNP gene encoding the prion protein (PrP). As the other sporadic or infectious prion disease forms, they are almost all characterized by the accumulation in the brain of an abnormal misfolded form of the patient's PrP. Brain extracts ca