Principles of Sex-based Differences in Physiology

✍ Scribed by Edward Bittar (Eds.)

• Publisher: Elsevier Science & Technology
• Year: 2004
• Tongue: English
• Leaves: 335
• Series: Advances in Molecular and Cell Biology 34
• Edition: 1
• Category: Library

✦ Synopsis

Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers. This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.

✦ Table of Contents

Content:
Foreword: a historical overview of advocacy for research in sex-based biology
Pages v-xiii
Sherry A. Marts, Sarah Keitt

Contents
Pages xv-xvii

Sex chromosomes Original Research Article
Pages 1-13
Monte E. Turner, Cathy Jenkins, Amy Milsted, Daniel L. Ely

Endocrine control of sexual differentiation: effects of the maternal–fetal environment and endocrine disrupting chemicals Original Research Article
Pages 15-37
Susan C Nagel, Frederick S vom Saal

General mechanisms of steroid receptors and receptor coregulator action Original Research Article
Pages 39-48
David G. Monroe, Thomas C. Spelsberg

Non-genomic actions of hormones Original Research Article
Pages 49-57
Richard H. Karas

Hormone receptor polymorphisms Original Research Article
Pages 59-69
Amanda M Shearman

Sex, hormones and the endothelium Original Research Article
Pages 71-84
Stephanie J. Murphy, Marguerite T. Littleton-Kearney, Louise D. McCullough, Patricia D. Hurn

Sex hormones and the vascular smooth muscle Original Research Article
Pages 85-103
Julia M. Orshal, Raouf A. Khalil

Cardiovascular membrane excitability and the influence of sex and sex steroids Original Research Article
Pages 105-114
Douglas K. Bowles, Meredith Hay

Sex-differences in electrophysiology of the heart and cardiac arrhythmias Original Research Article
Pages 115-130
Thai V. Pham, Michael R. Rosen

Sex differences in cardiac muscle and remodeling Original Research Article
Pages 131-145
Brian L. Stauffer, Leslie A. Leinwand

Reflex control of the circulation Original Research Article
Pages 147-166
Christopher T Minson

Sex differences in hypertension and renal injury Original Research Article
Pages 167-182
Jane F. Reckelhoff, Lourdes A. Fortepiani, Licy L. Yanes, Valeria E. Cucchiarelli

Influence of sex hormones on the neuromuscular junction Original Research Article
Pages 183-194
Gary C. Sieck, Carlos B. Mantilla

Sex and hormonal influences on skeletal muscle; differentiation and contractile mechanisms Original Research Article
Pages 195-208
Marybeth Brown

Sex-based differences in substrate metabolism Original Research Article
Pages 209-227
Tracy Horton, Barry Braun

Sex differences in skeletal development Original Research Article
Pages 229-245
Lorraine A Fitzpatrick

Sex differences in steroid-induced synaptic plasticity Original Research Article
Pages 247-258
Russell D. Romeo, Bruce S. McEwen

Hormones and the developing brain Original Research Article
Pages 259-279
Margaret M. McCarthy

Mechanisms of sex-based neuropathologies Original Research Article
Pages 281-294
Phyllis M. Wise, Dena B. Dubal, Shane W. Rau, Adrienne B. Cashion

Sex differences in autoimmunity Original Research Article
Pages 295-306
Thomas F. Fagan, Denise L. Faustman

Influence of hormones and sex on platelet functions Original Research Article
Pages 307-319
Muthuvel Jayachandran, Virginia M. Miller

Sex differences in wound healing Original Research Article
Pages 321-328
Gillian S Ashcroft

Subject index
Pages 329-333