Principles of Mucosal Immunology

✍ Scribed by Phillip D. Smith (editor), Richard S. Blumberg (editor), Thomas T. MacDonald (editor)

• Publisher: Garland Science
• Year: 2020
• Tongue: English
• Leaves: 615
• Edition: 2
• Category: Library

✦ Synopsis

This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.

✦ Table of Contents

Dedication
Contents
Preface
Contributors
PART I: DEVELOPMENT AND STRUCTURE OF MUCOSAL TISSUE
1 Overview of the mucosal immune system structure • Reinhard Pabst and Per Brandtzaeg
2 Phylogeny of the mucosal immune system • Robert D. Miller and Irene Salinas
3 Immunologic and functional differences among individual compartments of the mucosal immune system • Hiroshi Kiyono, Kohtaro Fujihashi, and Jiri Mestecky
4 Secreted effectors of the innate mucosal barrier • Michael A. McGuckin, Andre J. Ouellette, and Gary D. Wu
PART II: CELLULAR CONSTITUENTS OF MUCOSAL IMMUNE SYSTEMS AND THEIR FUNCTION IN MUCOSAL HOMEOSTASIS
5 Immune function of epithelial cells • Richard S. Blumberg, Wayne Lencer, Arthur Kaser, and Jerrold R. Turner
6 Intraepithelial T cells: Specialized T cells at epithelial surfaces • Hilde Cheroutre
7 T lymphocyte populations within the lamina propria • Thomas T. MacDonald and Antonio DiSabatino
8 Innate lymphoid cells • Gerard Eberl and Nicholas Powell
9 Role of regulatory T cells in mucosal immunity • Kenya Honda and Shohei Hori
10 Mucosal B cells and their function • Jo Spencer, Edward N. Janoff, and Per Brandtzaeg
11 Secretory immunoglobulins and their transport • Charlotte S. Kaetzel, Jiri Mestecky, and Jenny M. Woof
12 Role of dendritic cells in integrating immune responses to luminal antigens • Brian L. Kelsall and Maria Rescigno
13 Intestinal macrophages in defense of the mucosa • Lesley E. Smythies and Phillip D. Smith
14 Mucosal basophils, eosinophils, and mast cells • Edda Fiebiger and Stephan C. Bischoff
15 M cells and the follicle-associated epithelium • Hiroshi Ohno, Marian Neutra, and Ifor R. Williams
16 Lymphocyte trafficking from inductive sites to effector sites • Valerie Verhasselt, William Agace, Oliver Pabst, and Andrew Stagg
17 Mucosal tolerance • Charles O. Elson and Oliver Pabst
PART III: MICROBIAL COMMENSALISM
18 Recognition of microbe-associated molecular patterns by pattern recognition receptors • Elke Cario
19 Commensal microbiota and its relationship to homeostasis and disease • Jonathan Braun, Elaine Y. Hsiao, and Nicholas Powell
PART IV: GENITOURINARY TRACT
20 The immune system of the genitourinary tract • David A. MacIntyre and Kenneth W. Beagley
21 Mucosal immune responses to microbes in genital tract • Akiko Iwasaki
PART V: NOSE, AIRWAYS, ORAL CAVITY, AND EYES
22 Nasopharyngeal and oral immune system • Hiroshi Kiyono and Kohtaro Fujihashi
24 Ocular surface as mucosal immune site • Rachel R. Caspi and Anthony St. Leger
PART VI: INFECTIOUS DISEASES OF MUCOSAL SURFACES
25 Mucosal interactions with enteropathogenic bacteria • Nadine Cerf-Bensussan, Pamela Schnupf, Valérie Gaboriau-Routhiau, and Philippe J. Sansonetti
26 Helicobacter pylori infection • Diane Bimczok, Anne Müller, and Phillip D. Smith
27 Mucosal responses to helminth infections • William Gause and Richard Grencis
28 Viral infections • Sarah Elizabeth Blutt, Mary K. Estes, Satya Dandekar, and Phillip D. Smith
29 Infection-driven periodontal disease • Thomas E. Van Dyke and Mike Curtis
30 Mucosal vaccine strategies • Nils Lycke, Jan Holmgren, and Harry B. Greenberg
PART VII: SPECIFIC IMMUNE-MEDIATED DISEASES OF MUCOSAL SURFACES
31 Celiac disease • Bana Jabri and Ludvig M. Sollid
32 IgA nephropathy • Jan Novak, Bruce A. Julian, and Jiri Mestecky
33 Mucosal manifestations of immunodeficiencies • Scott Snapper, Jodie Ouahed, and Luigi D. Notarangelo
34 Inflammatory bowel disease • Giovanni Monteleone, Markus F. Neurath, and Britta Siegmund
35 Food allergies and eosinophilic gastrointestinal diseases • Cathryn Nagler and Glenn T. Furuta
Index