✦ LIBER ✦
Principal components regression for routine multicomponent UV determinations: A validation protocol
✍ Scribed by Paul J. Gemperline; Alger Salt
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 833 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0886-9383
No coin nor oath required. For personal study only.
✦ Synopsis
A validation protocol for multicomponent spectroscopic assays based on principal components regression is described. Factorial design and hypothesis tests are used to establish the linearity and absence of interaction between components in the regression model. Testing considers multiple response variables simultaneously so that correlation between residuals is properly treated. Assay reproducibility and sensitivity to related substances are evaluated.