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Primitive neuroectodermal tumors of the chest wall

✍ Scribed by Jerome Stefanko; Alan D. Turnbull; Larry Helson; Philip Lieberman; Nael Martini

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 330 KB
Volume: 37
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930370110

No coin nor oath required. For personal study only.

✦ Synopsis

Primitive neuroectodermal tumor (PNET) is a rare, highly malignant small-cell neoplasm that most often arises from the chest wall or paravertebral region. A patient is described from whom resection, intensive chemotherapy, and bone marrow transplant were unsuccessful. Eleven patients were treated between 1975 and 1985; there was only one longterm survivor (48 months) despite intensive multidisciplinary treatment. The median survival of 49 published cases was 9 months. Conservative resection minimizing disability, radiotherapy, and intensive chemotherapy remain valid options, but use of experimental agents as part of intial therapy seems justified. The role of autologous marrow transplant remains unclear.

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