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Priming of CD8 T Cells by Adenoviral Vectors Is Critically Dependent on B7 and Dendritic Cells but Only Partially Dependent on CD28 Ligation on CD8 T Cells

✍ Scribed by Nielsen, K. N.; Steffensen, M. A.; Christensen, J. P.; Thomsen, A. R.


Book ID
124167774
Publisher
American Association of Immunologists
Year
2014
Tongue
English
Weight
1016 KB
Volume
193
Category
Article
ISSN
0022-1767

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Dendritic cells (DC) play a crucial role in controlling the initiation and orientation of antigen (Ag)-specific immune responses. It is widely accepted that optimal T cell priming requires mature DC. Although the molecular events associated with DC activation have been extensively studied, little is