Priming effect of fibronectin on respiratory burst of human neutrophils induced by formyl peptides and platelet-activating factor
β Scribed by Lena Stanislawski; Trung Pham Huu; Axel Perianin
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 401 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0360-3997
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## Abstract Previous studies have shown that fibronectin (Fn) enhances phagocytosis and killing of antibodyβcoated bacteria by neutrophils and macrophages. In an attempt to understand the mechanism of this enhancement, we have investigated the effects of Fn on phagocytosisβrelated actin organizatio
We have shown that platelet-activating factor (PAF), a weak primary stimulus for neutrophil superoxide generation, synergistically enhances neutrophil oxidative responses to the tumor promoter phorbol myristate acetate (PMA). Since PMA is known to cause cytosol-to-membrane shift of calcium-activated