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Primidone and essential tremor

✍ Scribed by S. Seyfert; A. Honé; G. Holl

Publisher: Springer
Year: 1988
Tongue: English
Weight: 234 KB
Volume: 235
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00314310

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✦ Synopsis

To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%-69% for up to 28 h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethyl-malonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor.

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