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Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation

โœ Scribed by Bonnefont, J; Laforge, T; Plastre, O; Beck, B; Sorce, S; Dehay, C; Krause, K-H


Book ID
109842337
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
447 KB
Volume
18
Category
Article
ISSN
1350-9047

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Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s