Primary thrombophilia in Mexico: A prospective study

✍ Scribed by Ruiz-Arg�elles, Guillermo J.; Gonz�lez-Estrada, Sonia; Garc�s-Eisele, Javier; Ruiz-Arg�elles, Alejandro

• Book ID: 101215398
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 30 KB
• Volume: 60
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199901)60:1<1::aid-ajh1>3.0.co;2-q

✦ Synopsis

A group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied. Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation. Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency. No cases of abnormalities in antithrombin III, plasminogen, tissuetype plasminogen activator or plasminogen activator inhibitor were found. The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy. Am.