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Primary structures of human protein kinase C βI and βII differ only in their C-terminal sequences

✍ Scribed by Kyoko Kubo; Shigeo Ohno; Koichi Suzuki

Book ID
115919380
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
287 KB
Volume
223
Category
Article
ISSN
0014-5793

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✍ Amadeo M. Parissenti; Sandra A. Kim; Concettina M. Colantonio; Andrea L. Snihura 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 538 KB

This study demonstrates that the isolated regulatory (R) domain (amino acids 1 -270) of human protein kinase C a (PKCa) is a potent inhibitor of PKCP-I activity in a yeast expression system. The PKCa R domain fused to glutathione-S-transferase competitively inhibited the activity of yeast-expressed